Sarri apologises to irate Chelsea fans when confronted after Bournemouth defeat

first_img The Sun deals Son ban confirmed as Tottenham fail with appeal to overturn red card 3 Sarri then locked his stars in the dressing room following the match for clear-the-air talks.The Italian manager was stopped by angry Chelsea supporters who waited outside the stadium to make their feelings known, as shown in a video posted by The Sun. Boxing Day fixtures: All nine Premier League games live on talkSPORT Maurizio Sarri was confronted by angry Chelsea fans no dice LATEST PREMIER LEAGUE NEWS REVEALED Oxlade-Chamberlain suffers another setback as Klopp confirms serious injury Chelsea suffered their worst league defeat since 1996 Where Ancelotti ranks with every Premier League boss for trophies won tense Green reveals how he confronted Sarri after Chelsea’s 6-0 defeat at Man City He said sorry a number of times to the fans before leaving on good terms.The Chelsea manager was booed during the match for substituting new loan striker Gonzalo Higuain when his side were trailing 2-0. gameday cracker REVEALED huge blow Fans were less than impressed when Sarri substituted Higuain shining Which teams do the best on Boxing Day in the Premier League era? This led to chants of ‘you don’t know what you’re doing’ from a section of the visiting support.The defeat at Bournemouth was their heaviest in the Premier League since 1996 and saw Chelsea drop out of the Champions League places.They have the chance to bounce back this weekend as strugglers Huddersfield Town visit Stamford Bridge. Irate Chelsea fans who confronted Maurizio Sarri after the Blues’ drubbing at Bournemouth received an apology from their manager.Chelsea were thrashed 4-0 by the Cherries on Wednesday in their Premier League clash at the Vitality Stadium. One told the 60-year-old the performance was “disgusting” and called it the “worst performance he has ever seen”.While the Blues boss was also questioned on whether he had it in him to motivate the under-performing players.Sarri did not shy away from the complaints, though, and listened to what the fans had to say. 3 3 Man United transfer news live: Haaland ‘wants a change’, two players off in January Premier League Team of the Season so far, including Liverpool and Leicester stars last_img read more

This Week in Walt Disney World Weather — June 2, 2019

first_imgShare This!June is here! Welcome to summer in Florida. It’s a wild ride!Luckily, it’s just like that wildest ride in the wilderness, Big Thunder Mountain Railroad: if you’ve been on this ride a few times, it becomes a predictable (in a good way). You know where the big drops and the great views are. It’s our newbie friends who aren’t always sure what to expect the first time they queue up in the Florida sun. So, from thunderstorms to hurricane season, let’s talk all things summer!First, this week’s forecast. As June begins, a predictable summertime pattern begins to emerge, right on time. Humidity and heat will rule the mornings and middays, with temperatures spiking in the mid-90s, before afternoon sea breezes collide sometime after noon to produce some spotty thunderstorms. After storms push through, humidity will return for an overnight cooling into the upper 70s. Highs will remain above-average, with temperatures hitting 94-96 degrees in late afternoon, but days with storm coverage will be a little cooler.At the ParksSince the rainy season is still sputtering to a start and truly deep moisture isn’t in control yet, we will probably still see some very hot days with late evening storms, or even storms after sunset. This is a little against the typical mid-afternoon pattern. These storms can be really surprising when they roll up while you’re waiting for fireworks and dump some tropical downpours on you! They can also cause outdoor attractions to go down and stay down until after park close.With that in mind, keep a close eye on a good radar app if you’re saving some favorites for after dark. The storms can develop from nothing to something so quickly that just watching for approaching lightning might not help you beat them to the punch.Late evening storms drench Disney’s Boardwalk, July 2016 – a summer with a lot of hot days and late storms.Over the past few summers, I’ve observed a trend for these evening storms after a steamy, sunny day that just doesn’t want to cloud over. Eventually, even if the atmosphere isn’t particularly ripe for rainfall, all that searing heat just makes our swampland boil over into storms. It’s simply too hot to not rain. And that actually does make sense, in a Florida sort of way. For a full rundown on the rainy season pattern and what makes Florida tick, check out last week’s post.Here comes Hurricane Season!June, every TV meteorologist loves to remind us, is the beginning of hurricane season. But it’s the beginning of hurricane season the same way June 21st is the official first day of summer: it’s already hot by June 21st and we’re all generally in agreement that it’s been summer for a long time. Tropical systems can, and do, form outside of hurricane season. Still, it’s a good opportunity to review how hurricanes and tropical storms can affect your Disney vacation.Afternoon storms tower over the Seven Seas Lagoon.Seasonality: Late summer (August-October) is prime time for tropical systems. The Gulf of Mexico, the Caribbean Sea, and the Atlantic Ocean are all bathtub-warm by August, and warm water feeds tropical systems. Strength of Storms: The National Weather Service has established language for storms at each level of the Saffir-Simpson scale, which measures hurricane strength according to sustained winds at the storm’s core. When you’re dealing with a tropical system, you’re almost never dealing with the storm’s core, although we’ve had some brushes here in Central Florida. We can talk about those as needed later, but for now, here are some tips on what different storm levels can mean for your vacation, based on storms in recent history:Tropical Depressions, Waves, and Invests: These are big clusters of showers and thunderstorms at various stages of pre-storm development. If there’s a tropical depression heading towards your vacation, pack an extra pair of shoes—that way one pair can dry while you’re enjoying the parks. Basically: it’s going to rain. The rain may come in short, furious squalls with gusty winds, separated by long periods of showers or just gray weather. As a Floridian, I consider these storms a day or two of a break from the heat, and take the opportunity to have some fun in the rain.Tropical Storms: Ranging from a cluster of storms with some vaguely implied center to a tightly wrapped storm that’s almost at hurricane status, there’s a wide range of potential for tropical storm impacts. But for our purposes here, they generally cause rainy and windy weather for a day or two, with some embedded thunderstorms from time to time. As a Floridian, I tend to consider most tropical storms another break from the same-old same-old. They can cause flooding and problems for many people, but if you’re staying at Walt Disney World Resort, the most concern you’ll have is flight delays or cancellations from heavy weather sitting over the airport—and that can happen most days of summer, anyway.Hurricanes: A hurricane can be a lot of things, especially to a vacation. Erratic movers which fluctuate rapidly in strength, a hurricane can make the Orlando weather outlook change from washout to sunny and back to washout in just a few forecast cycles. Not only that, but everyone’s comfort level is different with hurricanes. It’s a uniquely personal thing to plan for. Parks do close for hurricane conditions, although they will reopen as soon as they’ve been cleared for safety, usually while the raindrops are still falling. You’ll have to wait it out at your resort. At Value and Moderate resorts, where doors open directly outside, guests are asked to stay in their rooms during the worst of the storm, which could get tiresome. At Deluxe resorts, campus-style properties like the Grand Floridian Resort have building lockdowns, meaning you won’t be able to go to the lobby building during the storm. In recent hurricanes, we’ve seen people lose a full park day to a lockdown or a park closure during the storm itself.But it’s important to note: every storm is different, and we can’t predict the way storms might affect you or your vacation. These are just observations based on storm behavior and WDW’s policies over the past few years.If you’re considering cancelling your trip due to a storm, you’ll want to be aware of the official Hurricane Warning should the National Weather Service post one. The official Hurricane Warning is what triggers Walt Disney World’s hurricane policy, and this specific cancellation policy applies to reservations before, during, and after a hurricane. You can find that policy at the Disney World website here.Will tropical systems affect us this year at Walt Disney World? Almost certainly. From tropical depressions to hurricanes, the only question is how much rain will fall, how hard the wind will blow, and how long the heavy weather will stick around. If the past is anything to go on, even a hurricane can’t keep the Magic Kingdom closed very long.Got any weather questions? Let us know in the comments.last_img read more

HR, Let’s Take Care of Us, Too

first_imgHuman resources professionals, today is World Mental Health Day.Let’s chat.I recently had an experience at an event where I got the opportunity to have extended sit-down conversations with HR professionals about what is keeping them up at night in terms of their workplace processes. As an HR practitioner for years, I’ve been there. The long days that turn into long nights, the weekdays that turn into working weekends, the 24/7 connected world that we live in. You can’t turn it off, you’re always on, and oftentimes taking care of others’ problems at work, and beyond.Let’s face it: as HR professionals we all act as counselors at times for our employees, and the topics we are asked to council on often go well beyond the scope of the workplace. It’s heavy stuff. I kept a box of tissues prominently on my desk and had to swap it out more frequently than I care to admit. Mostly it was the employees who used them. After they left my office, or in quiet times while reflecting on hard conversations, sometimes it was me.As I reflect on my experience meeting with HR folks from all industries, something struck me sharply and compelled me to convey a thought to be sure you know–or maybe just to remind you: you are not alone in your HR struggles.ACA compliance, HIPAA regulations, employee relations issues, onboarding, terminations, recruitment, retirement, skills shortages—all the moments that matter for employees are things that keep you up at night because they are complex and oftentimes difficult to navigate. This is true whether you are an HR department of one, or you work for a large company with several HR employees.Maybe you feel like you are the only one who doesn’t have it all figured out. Good news! I’m here to tell you you’re not alone. As HR practitioners we are all in this together—a largely unspoken (until SHRM conferences!) kinship of sorts, one that when we can get together and talk, there are moments that make us say, “I thought I was the only one.” It comforting to then realize you’re not!As I sat with these professionals from all HR walks of life, I sensed that they took solace in the fact that “I’ve been there too,” and could empathize with what they were feeling and experiencing in their HR careers, and their everyday work life. They were also intrigued by what technology could do to help them find the right balance for their companies and make it easier on them.There are solutions out there to help you, the HR professional, take care of you, take stress away, and be more productive. Consider this your call to action to be good to yourself simply by asking for what it is you need to do your job better, taking some time off, unplugging, or doing whatever it is to find your Zen.Your future self will thank you.last_img read more

Movable Type Goes Open Source Today

first_imgTop Reasons to Go With Managed WordPress Hosting Related Posts richard macmanus Why Tech Companies Need Simpler Terms of Servic… Tags:#Product Reviews#web center_img Today Six Apart is officially making its Movable Type publishing platform open source, just under four months after the launch of Movable Type 4 and six months after the open sourcing announcement in June. This means that as of today, MT users can freely modify, redistribute, and use Movable Type for any purpose they choose. Importantly, it also means that Six Apart has finally removed the one major advantage that WordPress has had over Movable Type – that it is open source. I’m sure representatives of both companies will argue that they still have advantages over the other (in fact, they usually do so in the Read/WriteWeb comments!). But given Movable Type’s history – MT was once the darling of early adopter bloggers, but when Six Apart introduced licensing fees the tide quickly turned towards WordPress – the open sourcing is both a necessary and welcome move by Six Apart.MTOS (Movable Type Open Source) is an open source project that will consist of a GPL-licensed version of Movable Type 4.0 and resources for the community of Movable Type developers. It was originally slated for Q3 release, but was pushed back to Q4 – today to be exact. The main points:MTOS has every feature in Movable Type 4.0, along with several new minor improvements and bug fixes.All plugins, themes, templates, designs, and APIs that work with MT4 work with MTOS.MTOS has built-in support for an unlimited number of blogs, an unlimited number of authors, and sign-in with OpenID.Six Apart will be adding additional paid benefits for paid users of Movable Type in the future, with benefits like improved technical support and custom add-ons such as plugins or themes.You can download MTOS at movabletype.org and find out how to contribute to the MTOS project and the MT community.MTOS support is provided by other members of the community. You can buy a standard paid license for one of the existing Movable Type products if you’d like professional support directly from Six Apart.In a blog post, Six Apart’s Anil Dash says that the open sourcing of MT is all about “freedom”. No doubt aware that Movable Type has some work to do to position itself as an open source publishing system, Dash claims that there is “a tradition of openness that Movable Type has embodied for over six years”. He notes that “there’s always been a free (as in beer) version of Movable Type” and “from TrackBack to Atom to OpenID, we’ve always released standalone open-source implementations of the key technologies that we’ve created or popularized with Movable Type.”Those are good points by Dash, but really the open sourcing was forced on them by WordPress’ success over the past 2-3 years. I’m glad to see Movable Type finally out in the open, because it’s the system we use here at RWW (although we also use WordPress on some of our network blogs). In the end, the users will win when there are two quality open source publishing platforms available! A Web Developer’s New Best Friend is the AI Wai… 8 Best WordPress Hosting Solutions on the Marketlast_img read more

New software can track many individuals in a crowd

first_img A. Dehghan et al., IEEE Transactions on Pattern Analysis and Machine Intelligence PP, 99 (24 March 2017) © IEEE dibrova/iStockphoto In 2015, more than 2000 people died in a stampede during the Hajj pilgrimage in Saudi Arabia. In 2013, two terrorists deposited backpacks carrying bombs at the Boston Marathon and slipped away, leaving three spectators to die. If technology could in real-time track and analyze the movement of individuals in dense crowds, we might better predict dangerous pileups or spot suspicious behavior, saving many lives a year. A pair of researchers has just taken a large step in that direction, writing software that for the first time can track hundreds of people in a crowd simultaneously.Following the paths of many individuals at the same time is enormously difficult, even for humans. Previous computer-based efforts to analyze dense crowd movement have focused on tracking one individual at a time in recorded video. But there are problems with that method. First, you have to run the programs over and over again for each person you want to track. Second, the programs tend to identify people in each frame of a video based on appearance—but heads and faces can be hard to distinguish from above, especially in tight crowds and low-resolution video. The new research, which will be published in IEEE Transactions on Pattern Analysis and Machine Intelligence, finds a way to increase both the efficiency and accuracy of tracking a person, enabling a software program to finally follow many people at the same time.The trick involves predicting where an individual will go next. The researchers wrote a mathematical function that analyzes five factors, based on previous frames of a video, to anticipate where each person will be in the current frame. One is appearance: Which patches of pixels resemble the target from the previous frame? Another is target motion: Where could the target be based on speed and direction? A third is neighbor motion: If the target is obscured, the program guesses on location based on the motion of the person’s neighbors. Fourth is spatial proximity: The program won’t guess that two people are in the same place, standing on top of one another. And last is grouping: If the program identifies a few people walking in a group, it will assume that they’ll retain the same formation.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)For a group of more than about 10 people, a perfect mathematical solution to the formula is impossible, because of the number of targets and interactions between them. So the team uses an iterative algorithm to produce a slightly rougher but easier-to-calculate prediction of each person’s location frame by frame. “It’s not feasible to find an exact solution for a large number of targets,” says Afshin Dehghan, a computer scientist who conducted the work with Mubarak Shah while at the University of Central Florida in Orlando. “We introduced a new technique that is actually popular in other areas, like math.” (It’s a version of what’s called the Frank-Wolfe algorithm, if you’re curious.)To test their method, the researchers analyzed nine crowd videos that had been used in previous research, covering marathons, commuters, a crosswalk, a train station, an airport, and a Hajj pilgrimage. The crowd sizes ranged from 57 to 747 people. By one measure, the program’s accuracy at tracking everyone in a video ranged from 67% to 99%. That performance matched or greatly exceeded five comparison algorithms—all of which tracked people one by one. Grand Central Terminal in New York City. New software can track many individuals in a crowd center_img Software tracks marathon runners. By Matthew HutsonApr. 10, 2017 , 9:00 AM Incorporating collective movements was key to the program’s success. “There are group dynamics at play when you’re with other people, especially in a dense situation,” says Aniket Bera, a computer scientist at The University of North Carolina in Chapel Hill, who studies crowd behavior but was not involved in the work. “That information has been exploited in this paper.”Hamid Rezatofighi, a computer scientist at the University of Adelaide in Australia, who has worked on multitarget tracking, says the technique is interesting. But he questions its practicality, because a user has to manually select targets to track. That means at the start of a video, users have to click on each person they want to follow.And currently the method does not work in real time when tracking hundreds of people—it can take close to a second per frame to finish the needed calculations—but Dehghan notes that “the code has a lot of room to be optimized.” He’s hoping to release it publicly.“There are many applications for tracking individuals in a crowd,” Dehghan says. You might analyze flow to design public spaces better and prevent overcrowding or bottlenecking, or program rules that spot anomalous behavior in security videos, such as lingering or stalking or erratic walking. Crowds form not just at marathons and pilgrimages, of course, but at concerts and political rallies and soccer games. In fact, the research was partially funded by the Qatar National Research Fund, as Qatar will be hosting the 2022 World Cup and wants to assure crowd safety. (Where should entrances and exits be placed? Can a terrorist be identified before detonating a bomb?)And humans aren’t the only ones to flock together. The same technique, Dehghan says, could be used to follow members of herds of animals or schools of fish for scientific research. Or cells in medical imaging to diagnose disease or understand healthy functioning. “Tracking in dense crowds is a relatively unexplored problem,” he says.last_img read more

Skepticism surfaces over CRISPR human embryo editing claims

first_img By Kelly ServickAug. 31, 2017 , 12:28 PM OHSU Skepticism surfaces over CRISPR human embryo editing claims When the first U.S. team to edit human embryos with CRISPR revealed their success earlier this month, the field reeled with the possibility that the gene-editing technique might soon produce children free of their parents’ genetic defects. But the way CRISPR repaired the paternal mutation targeted in the embryos was also a surprise. Instead of replacing the gene defect with strands of DNA that the researchers inserted, the embryos appeared to use the mother’s healthy gene as a template for repairing the cut made by CRISPR’s enzyme.But such a feat has not been observed in previous CRISPR experiments, and some scientists are now questioning whether the repairs really happened that way. In a paper published online this week on the preprint server bioRxiv, a group of six geneticists, developmental biologists, and stem cell researchers offers alternative explanations for the results. And uncertainty about exactly how the embryos’ DNA changed after editing leaves many questions about the technique’s safety, they argue. (The authors declined to discuss the paper while it’s being reviewed for publication.)Embryologist Shoukhrat Mitalipov of Oregon Health and Science University in Portland, who led the now-disputed experiments, released a statement saying that his team stands by its explanation. “We based our finding and conclusions on careful experimental design involving hundreds of human embryos,” it says.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)center_img In the 2 August Nature paper, Mitalipov and his collaborators showed they could bump up the efficiency of human embryo editing by inserting the CRISPR machinery earlier in development than previous experiments. When they combined healthy eggs with sperm bearing a disease-causing mutation and immediately added CRISPR, they found that 72% of the resulting embryos were free of the mutation—rather than the expected 50% that would have avoided inheriting the harmful gene anyway.Although the researchers inserted short strands of DNA as templates for repair, the cells didn’t seem to take them up; those specific sequences were absent from the embryos. The cells must have relied instead on the nonmutated sequence in the egg donor’s DNA when making the repairs, the team concluded.The bioRxiv response, led by developmental biologist Maria Jasin of Memorial Sloan Kettering Cancer Center in New York City and Columbia University stem cell biologist Dieter Egli, challenges that interpretation. The authors, which also include well-known CRISPR researcher and Harvard University geneticist George Church, say that the Nature paper goes against conventional wisdom about how embryos are organized early in development. Right after an egg is fertilized, the DNA from the sperm and the egg aren’t believed to be in close enough proximity to interact or share genes, they explain.Stem cell researcher Junjiu Huang of Sun Yat-Sen University in Guangzhou, China, who led the first published study of CRISPR editing of a human embryo, isn’t on the bioRxiv paper, but shares that concern. It’s not unexpected for a cell to use its own sequences to guide repair, he notes. In his group’s study, which used nonviable embryos, a gene related to the CRISPR-targeted gene seemed to function as a template. But that gene was on the same chromosome as CRISPR’s edits. Here, the sperm and egg nuclei are seemingly too far apart to cooperate in the repairs, he says.The preprint authors lay out two other scenarios for what Mitalipov’s team saw. It’s possible that some of the embryos didn’t take up paternal DNA at all, and thus never inherited the mutation to begin with. In some in vitro fertilization procedures, embryos can occasionally start to develop from maternal DNA alone, and the study didn’t rule out this phenomenon for every embryo, they say.They also suggest that mutated paternal gene could have been snipped out of young embryos but never actually replaced with a healthy version. CRISPR’s cuts can sometimes cause chunks of DNA to be removed from the strand before the two cut ends are rejoined, they note. That would mean no detectable mutation—but it could also mean missing sections of DNA that could have unknown consequences for the embryo.This possibility of “allele dropout” has been the subject of discussion in the field ever since the Nature paper was published, says developmental biologist Robin Lovell-Badge of the Francis Crick Institute in London. Many scientists are now waiting for a response from Mitalipov, he says.In his statement, Mitalipov promised to “respond to [the] critiques point by point in the form of a formal peer-reviewed response in a matter of weeks.” He also urged follow-up to resolve the matter. “We encourage other scientists to reproduce our findings by conducting their own experiments on human embryos and publishing their results.”*Update, 1 September, 1:30 p.m.: The new version of this story has additional comments from several researchers and clarifies the authorship of the preprint. Newly fertilized (left) and later-stage (right) human embryos that have had a disease mutation corrected by the CRISPR editing system.last_img read more

These caterpillars can camouflage themselves, even when blindfolded

first_img Most animals that change color to match their surroundings can see what these surroundings look like. But the peppered moth caterpillar can do this with its eyes closed, according to a new study, and scientists have figured out how. Researchers raised more than 300 larvae of the peppered moth (Biston betularia) in the lab. After the caterpillars grew up a bit, the scientists placed them in different boxes containing artificial sticks painted black, brown, green, and white (pictured). Some of the larvae were blindfolded using black paint.The blindfolded caterpillars changed their entire body color to match the stick they were sitting on as well as their seeing counterparts did, the team reports in Communications Biology. When the researchers placed the caterpillars in boxes containing different colored sticks, about 80% of the larvae, both blinded and sighted, chose to rest on sticks that matched their body color.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)On closer examination, the scientists discovered the peppered moth caterpillar turns on genes responsible for vision not only in its head, but also in its skin. The bugs have rather poor eyesight and sit on branches with their heads tilted away, so their eyes may not always be on the branch. This, along with their very slow color change can make them sitting targets. It’s likely that the caterpillars evolved such a dual mechanism of color sensing to give them a leg up in outwitting their hunters, the team speculates. These caterpillars can camouflage themselves, even when blindfolded Ilik Saccheri center_img By Lakshmi SupriyaAug. 7, 2019 , 12:55 PMlast_img read more

Modi congratulates Indian hockey, women’s relay teams

first_imgPrime Minister Narendra Modi congratulated the Indian hockey team and the women’s 4x400m relay team after they won gold medals at the Asian Games on October 2.Modi also congratulated all the medal winners from India, saying they have made the country proud.”Very good day for India at the Asian Games. Congrats to our Hockey Team and congrats to our women athletes for the Gold in 4 x 400 metres relay,” Modi said in a tweet.”I have been closely following India’s progress at the Asian Games and I congratulate every medal winner. You make India very proud,” he added.The Indian hockey team defeated Pakistan 4-2 via penalties in the final after scores were level 1-1 in regulation time.last_img read more

Long wait for Muhammad Ali to regain world heavyweight crown he lost to Leon Spinks

first_imgMuhammad Ali – ‘the long, hard climb back to the top’The international following that the pied piper of boxing, Muhammad Ali, has attracted, may have a long, frustrating wait before their ageing hero gets a chance to regain the world heavyweight crown he lost to unknown Leon Spinks last month.While,Muhammad Ali – ‘the long, hard climb back to the top’The international following that the pied piper of boxing, Muhammad Ali, has attracted, may have a long, frustrating wait before their ageing hero gets a chance to regain the world heavyweight crown he lost to unknown Leon Spinks last month.While grandiose plans were being formulated to arrange an early re-match between Ali and Spinks, heavyweight contender Ken Norton put a spoke in the wheel by surprisingly accepting an offer to fight Spinks in May or June.Boxing circles were taken totally unawares by Norton’s decision – Norton will earn $200,000 for the fight, which is chicken feed by current boxing standards, and most people had expected Norton to reject the offer. Norton’s acceptance, however, has thrown into disarray the complicated financial wheeling and dealing that governs the highest-paid sport in the world. By fighting Norton, Spinks stands to earn only $1 million, instead of the $5 million he would have pocketed from a re-match with Ali.This unusual situation has arisen purely because Spinks, who has only fought eight professional bouts so far, was universally expected to be massacred by Ali in their Las Vegas title fight. Spinks’ promoters, Top Rank, had drawn up a contract which gave them the right to promote Spinks’ first six title defences in the unlikely event of his beating Ali.Because of the overwhelming odds against a Spinks’ win, major television networks were wary of forking out the $4 million Top Rank demanded for televising the title fight in Las Vegas. Top Rank finally got CBS to agree, but only after promising them the televising rights for Spinks’ next fight (if he won) for a mere $1.5 million, against anyone but Ali.advertisementSpinks’ unexpected win over Ali has now backfired on his promoters, who are desperately trying to back-pedal on the deal. “We called their bluff,’ said Norton, “they were hoping we’d turn it down but I was over the barrel and had to go for it. It kind of backfired on them.”What is worse, as far as both Top Rank and Spinks are concerned is that Norton, who has beaten Ali once before, is more than likely to beat Spinks, thus destroying the current champion’s chances of getting his hands on the really big money. The only hope that Top Rank now have is to offer Norton a larger slice of boxing’s financial cake, if he agrees to let Ali have his re-match with Spinks first and then take on the winner later in the year.last_img read more

Vipers Strike In TFSA Finals

first_imgIn the B Division, the Northern Vipers went into the game as underdogs with the Central Scorpions previously undefeated in the season. However it was the Vipers who started well gaining an early advantage over their more fancied opponents to take a 2-0 buffer into half-time.Not to be outdone the Scorpions scored first in the second half to cut the deficit to one (2-1) however the young Vipers rallied and hit straight back to score twice in quick succession to extend their lead to 4-1. Despite a late touchdown by the Scorpions it was too little too late as the Northern Vipers claimed an upset win to claim the B Division championship, 4-2.SA Heat 18’s hopeful, Ned Davies starred for the Vipers scoring three touchdowns whilst Pat Organ also crossed the line, while for the Scorpions Paul Avers and Emily Gale were the scorers.The A Grade final also featuring the Northern Vipers and Central Scorpions was billed as a clash of the titans with both teams playing out a 7-all draw in their minor round clash. Many predicted a tight contest and the game certainly lived up to expectations and did not disappoint.In one of the most exciting TFSA League finals in many years both sides attacked hard in the first half but the defence of both teams was strong ensuring a tight, tense contest. It was the Central Scorpions who enjoyed most of the attack in the first half and when they broke the deadlock right on half-time they went into the break with a slight advantage leading 3-2. After the break it was the Vipers who struck first to get the crucial first touchdown which tied the game up again at 3-all, after which a highly entertaining tense nine minutes of defensive play by both teams ensued which was only broken by an unfortunate injury to Central Scorpions playmaker, Jess Ryan.The break gave both teams an opportunity to catch their breath and reload. The brilliant touches on each team’s score lines continued however the Vipers managed to break through at the 13 minute mark to hit the front for the first time in the match, 4-3. With the momentum seemingly shifting to the Vipers late in the match the Scorpions needed to dig deep and they did just that with Luke Thornton making a great play as half to set up his teammate on the wing to level things up once again with 90 seconds remaining, 4-all.No side managed to score in the last 90 seconds and when the siren sounded scores were locked away at 4-4 sending the final to a drop off.The Vipers had the tap when the game resumed and put together an amazing first set of six complete with a monster long ball from Tim Glazebrook which found its target and the Vipers scored on their last touch to put them 5-4 up and in a commanding position.However the drama of this match was not over just yet with the Central Scorpions getting the ball across the line on their last touch however a brilliant touch by the Vipers defence brought the referees together for a conference and rightfully so a touch was called sparking celebrations from the Vipers players who claimed the championship 5-4 in amazing fashion.The Vipers celebrations continued when they were announced as Regional Champions, making it back-to-back TFSA league championships for the Northern Vipers.Three Vipers players were also named series MVP’s with Shane ‘Kiwi’ Marshall from the Eastern Stingrays also featuring in the MVP’s. Mixed TFSA League Most Valuable PlayersB Grade MVP Female – Amanda Sheeky (Northern Vipers)B Grade MVP Male – Shane Marshall (Eastern Stingrays)A Grade MVP Female – Kelly Rowe (Northern Vipers)A Grade MVP Male – Tim Glazebrook (Northern Vipers)The Mixed TFSA League was a resounding success and the final matches demonstrate the improvement in game standard within South Australia with few blow outs occurring this series and a very even playing field. It was great to see so much youth participating in the series with most regions fielding up to 15 under 16’s in their teams which has enormous benefits for the development of the game.TFSA congratulates all teams and thanks its referees, regional coordinators, SOAP members, selectors and players for their efforts this season.This series marked the end of standalone Mixed TFSA League competition with TFSA League expanding to incorporate one large series annually incorporating Mixed, Women’s and Men’s divisions to occur from November to February. This move has been brought about through growth in player numbers.To find out more about TFSA, please visit their website:www.touchsa.com.aulast_img read more